Metabolic Symbiosis Between Cancer Cells and Endothelial Cells: A Key Driver of Tumor Angiogenesis.

This chapter explores the critical role of angiogenesis in cancer, focusing on the metabolic processes involved in angiogenesis, particularly the metabolic remodeling of endothelial cells (ECs) and the symbiosis between cancer cells and ECs, which drive vascular development. Key topics include the influence of hypoxia and oxidative stress, and the reliance on different metabolic sources on EC function, as well as how various pro-angiogenic factors contribute to tumor vascularization. The importance of metabolic flexibility in ECs and its implications for cancer treatment will also be highlighted.