Study of ameliorative effect of Allium cepa essential oil and purple cabbage (Brassica Oleracea Var. Capitata F. Rubra) leaves extract on CCl4 induced nephrotoxicity in rats.

In human body kidney pair acts as an essential excretory organ which keeps up the acid/base equalization. The onion and cabbage compounds play vital role as nephroprotective, because toxicity induced free radicals are neutralized by antioxidant substances present in onion (Allium Cepa) and cabbage (Brassica oleracea). This research helps to find which compound has better nephroprotective activity. In this study 25 albino rats were used as models for studying carbon tetrachloride induced nephrotoxicity. The rats were divided into 5 groups. Control group received no treatment, 2nd group got only CCl4, 3rd group received CCl4 and purple cabbage leaves extract, 4th group received CCl4 and onion oil (5 ml/kg) and 5th group received CCl4 and both onion essential oil and purple cabbage leaves extract. At 15th day, rats were euthanized, blood and kidney samples of all groups were collected for histopathology of kidney and serum testing, includes BUN, creatinine, albumin and electrolytes levels. CCl4 administration altered creatinine, albumin protein and blood urea nitrogen level of serum. It also changed the electrolytes' concentration in treated group animals as compared to control group rats. The extract of purple cabbage leaves and onion essential oil showed a protective effect against nephrotoxicity among treated groups of rats.