Redox report : communications in free radical research · 2026
Protective effects of Angelica dahurica polysaccharide on oxidative stress and liver injury induced by ovariectomized/D-galactose in rats.
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He Xue-Qin, Li Yi-Zhang, Xu Li-Ba, Wu Chun-Feng, Wei Du-Dong, Liu Hao-Yu, Qiu Fen
Аннотация
BACKGROUND: Oxidative stress-induced liver injury can progress to severe hepatic conditions. Polysaccharides are promising therapeutic agents, but the protective effects of Angelica dahurica polysaccharide (ADP) against this injury remain unclear.
PURPOSE: This study was conducted to elucidate ADP's protective effects and underlying molecular mechanisms in Ovariectomize/D-galactose (OVX/D-Gal) rats.
METHODS: Fifty female OVX rats and ten sham-operated (SO) rats were randomly divided into six groups. Except SO group, rats were administered the corresponding doses of ADP and resveratrol respectively, and the model was established by 49-day daily subcutaneous D-Gal injection. Serum and liver samples were collected to examine the hepatic histopathological changes, oxidative stress-related biomarkers, inflammatory factors, and protein and gene expression levels.
RESULTS: ADP reduced serum ALT and AST levels (P < 0.01) and improved liver histology. ADP increased SOD and GSH-Px activities , decreased MDA levels (P < 0.05). ADP also lowered pro-inflammatory cytokines levels, upregulated Nrf2, HO-1, and NQO-1 expression, promoted Bcl-2 and suppressed Bax and cleaved caspase-3 (P < 0.05).
CONCLUSIONS: ADP alleviated OVX/D-Gal-induced oxidative stress and liver injury by increasing antioxidant capacity, inhibiting apoptosis, attenuating inflammation, and activating Nrf2/HO-1/NQO-1 signaling pathway.
PURPOSE: This study was conducted to elucidate ADP's protective effects and underlying molecular mechanisms in Ovariectomize/D-galactose (OVX/D-Gal) rats.
METHODS: Fifty female OVX rats and ten sham-operated (SO) rats were randomly divided into six groups. Except SO group, rats were administered the corresponding doses of ADP and resveratrol respectively, and the model was established by 49-day daily subcutaneous D-Gal injection. Serum and liver samples were collected to examine the hepatic histopathological changes, oxidative stress-related biomarkers, inflammatory factors, and protein and gene expression levels.
RESULTS: ADP reduced serum ALT and AST levels (P < 0.01) and improved liver histology. ADP increased SOD and GSH-Px activities , decreased MDA levels (P < 0.05). ADP also lowered pro-inflammatory cytokines levels, upregulated Nrf2, HO-1, and NQO-1 expression, promoted Bcl-2 and suppressed Bax and cleaved caspase-3 (P < 0.05).
CONCLUSIONS: ADP alleviated OVX/D-Gal-induced oxidative stress and liver injury by increasing antioxidant capacity, inhibiting apoptosis, attenuating inflammation, and activating Nrf2/HO-1/NQO-1 signaling pathway.