Pd-Catalyzed [2 + 2 + 2] Cyclization of Alkyne-cyclohexadienones and O-Akynyl Benzenesulfonamides for Construction of Fused Tricyclic Hydronaphthofurans.

A palladium-catalyzed [2 + 2 + 2] cyclization of 1,6-enynes with unsymmetrical alkynes has been successfully accomplished, resulting in the formation of a series of fused tricyclic hydronaphthofurans with high stereo- and regioselectivity in a single step. This reaction demonstrates 100% atomic economy and exhibits a broad substrate scope.