Electrospun Polyvinyl Alcohol/Polyethylene Oxide Loaded With Cisplatin as a Potential Candidate for Anticancer and Antibacterial Drugs.

One of the most crucial approaches to treating some aggressive diseases, like cancer, is to either discover new medications or to refine and adapt those that already exist. Among these approaches is the drug delivery system, which could help reduce drug doses and side effects. In the existing endeavor, cisplatin (CIS) was loaded on polyvinyl alcohol/polyethylene oxide nanofiber (PVA-PEO-CIS) by the electrospinning method. The fabricated nanofiber was characterized, and its anticancer impact against cervical cancer cells (HeLa) was measured. Also, its antibacterial effect was studied. The obtained findings indicated that (PVA-PEO-CIS) nanofiber inhibits HeLa growth with a half-maximal inhibitory concentration (IC50) of 19.82 µg/mL compared to free CIS (IC50 = 26.31 µg/mL). Importantly, the nanofiber was less toxic to normal WI-38 cells compared to free CIS. The improvement of the anticancer action of CIS was consistent with CIS release studies that indicated about 50% of CIS was released from nanofibers within 8 h. Further, PVA-PEO-CIS nanofiber showed potent bactericidal impact against different bacterial strains, including Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. For several biological applications, including tumor therapy and antibacterial research, PVA-PEO-CIS may be a potential medication candidate.