Frontiers in neurology · 2025
Association of free-water imaging data for the cholinergic nucleus with the motor function and subtypes in Parkinson's disease.
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Xu Shanhu, Si Xiaoli, Cai Miao, Fu Fengli, Tian Jun, Zhang Baorong, Liu Xiaoli
Аннотация
BACKGROUND: Despite the importance of clinical heterogeneity in Parkinson's disease (PD), its underlying pathophysiology remains unclear.
OBJECTIVE: This study aimed to distinguish the association of free-water (FW) imaging data for the cholinergic nuclei with the motor subtypes of PD.
METHODS: The study included 150 cases of idiopathic PD from the Parkinson's Progression Markers Initiative cohort. FW imaging, including FW-corrected diffusion tensor imaging, was used to extract structural metrics from cholinergic nucleus 4 (Ch4) in the basal forebrain and the pedunculopontine nucleus. The motor subtypes were classified as tremor-dominant (TD, n = 99) and non-tremor-dominant (non-TD, n = 51). Statistical analyses were performed at baseline and the 4-year follow-up.
RESULTS: At baseline, FW value for Ch4 (FW-Ch4) was correlated with the tremor subscore, while FW-corrected fractional anisotropy in Ch4 (FA-t-Ch4) was negatively correlated with the rigidity subscore. However, the TD and non-TD groups showed no differences in cholinergic FW imaging data. Among the 84 patients who were followed-up, 36.36% (20/55) in the TD group and 34.48% (10/29) in the non-TD group showed a subtype shift after 4 years. Multivariate binary logistic regression analysis showed that the normalized FW value for Ch4 (nFW-Ch4) was a predictor of subtype at the 4-year follow-up (p = 0.041). In the TD subgroup, both nFW-Ch4 (p = 0.015) and normalized FW-corrected mean diffusivity in Ch4 (MD-t-Ch4) (p = 0.013) predicted subtype stability. The area under the receiver operating characteristic curve values were 0.69 and 0.73, respectively.
CONCLUSION: Tremor and rigidity subscores were correlated with Ch4 FW imaging data. Moreover, Ch4 FW imaging predicted the motor subtype at the 4-year follow-up, especially identifying potential postural instability and gait difficulty (PIGD) subtype converters from the TD group.
OBJECTIVE: This study aimed to distinguish the association of free-water (FW) imaging data for the cholinergic nuclei with the motor subtypes of PD.
METHODS: The study included 150 cases of idiopathic PD from the Parkinson's Progression Markers Initiative cohort. FW imaging, including FW-corrected diffusion tensor imaging, was used to extract structural metrics from cholinergic nucleus 4 (Ch4) in the basal forebrain and the pedunculopontine nucleus. The motor subtypes were classified as tremor-dominant (TD, n = 99) and non-tremor-dominant (non-TD, n = 51). Statistical analyses were performed at baseline and the 4-year follow-up.
RESULTS: At baseline, FW value for Ch4 (FW-Ch4) was correlated with the tremor subscore, while FW-corrected fractional anisotropy in Ch4 (FA-t-Ch4) was negatively correlated with the rigidity subscore. However, the TD and non-TD groups showed no differences in cholinergic FW imaging data. Among the 84 patients who were followed-up, 36.36% (20/55) in the TD group and 34.48% (10/29) in the non-TD group showed a subtype shift after 4 years. Multivariate binary logistic regression analysis showed that the normalized FW value for Ch4 (nFW-Ch4) was a predictor of subtype at the 4-year follow-up (p = 0.041). In the TD subgroup, both nFW-Ch4 (p = 0.015) and normalized FW-corrected mean diffusivity in Ch4 (MD-t-Ch4) (p = 0.013) predicted subtype stability. The area under the receiver operating characteristic curve values were 0.69 and 0.73, respectively.
CONCLUSION: Tremor and rigidity subscores were correlated with Ch4 FW imaging data. Moreover, Ch4 FW imaging predicted the motor subtype at the 4-year follow-up, especially identifying potential postural instability and gait difficulty (PIGD) subtype converters from the TD group.