Cureus · 2025
Esophageal Variceal Grading and Platelet Count in Patients With Liver Cirrhosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Farooq Muhammad, Sadiq Usman, Wadud Qaiser, Ali Abbas, Khawar Rahman Dania, Imran Muhammad, Safeer Mahnoor, Habib Syeda Hafsa, Habib Tayaba Syed
Аннотация
BACKGROUND: Esophageal varices represent a critical consequence of liver cirrhosis, with the risk of hemorrhage closely associated with the grade of the varices. Upper gastrointestinal endoscopy (UGIE) is the definitive method for detection; nonetheless, it is invasive and resource-demanding. Recognizing straightforward, non-invasive indicators like platelet count may assist in risk stratification and prioritize endoscopic screening in patients with cirrhosis.
OBJECTIVE: This study aimed to ascertain the correlation between esophageal variceal grading and platelet count in individuals with liver cirrhosis and to assess the clinical relevance of thrombocytopenia as a predictor of high-grade varices.
MATERIALS AND METHODS: This observational, descriptive study was performed from August 2022 to August 2023. One hundred twenty cirrhotic individuals had a UGIE assessment for esophageal varices. Demographic, clinical, and laboratory data, including platelet counts, were documented. Patients were classified according to platelet count (>150, 100-150, and <100×10⁹/L) and variceal grades (I-III). The correlation between platelet count and variceal grade was evaluated utilizing chi-squared tests, odds ratios (OR), and multivariate logistic regression in IBM SPSS Statistics for Windows, V. 27.0 (IBM Corp., Armonk, NY, USA).
RESULTS: A notable adverse correlation was identified between platelet count and the severity of esophageal varices. Patients exhibiting reduced platelet counts were more predisposed to high-grade (Grade III) varices, with thrombocytopenia <100×10⁹/L serving as an independent predictor of high-grade varices, even after controlling for confounding variables. The Child-Turcotte-Pugh Class C was correlated with high-grade varices, although age and ascites were not significant predictors.
CONCLUSION: Thrombocytopenia is markedly correlated with advanced stages of esophageal varices and may function as an effective, non-invasive indicator for detecting high-risk cirrhotic patients. Integrating platelet count into clinical decision-making may enhance risk classification and refine endoscopic screening strategies in resource-constrained environments.
OBJECTIVE: This study aimed to ascertain the correlation between esophageal variceal grading and platelet count in individuals with liver cirrhosis and to assess the clinical relevance of thrombocytopenia as a predictor of high-grade varices.
MATERIALS AND METHODS: This observational, descriptive study was performed from August 2022 to August 2023. One hundred twenty cirrhotic individuals had a UGIE assessment for esophageal varices. Demographic, clinical, and laboratory data, including platelet counts, were documented. Patients were classified according to platelet count (>150, 100-150, and <100×10⁹/L) and variceal grades (I-III). The correlation between platelet count and variceal grade was evaluated utilizing chi-squared tests, odds ratios (OR), and multivariate logistic regression in IBM SPSS Statistics for Windows, V. 27.0 (IBM Corp., Armonk, NY, USA).
RESULTS: A notable adverse correlation was identified between platelet count and the severity of esophageal varices. Patients exhibiting reduced platelet counts were more predisposed to high-grade (Grade III) varices, with thrombocytopenia <100×10⁹/L serving as an independent predictor of high-grade varices, even after controlling for confounding variables. The Child-Turcotte-Pugh Class C was correlated with high-grade varices, although age and ascites were not significant predictors.
CONCLUSION: Thrombocytopenia is markedly correlated with advanced stages of esophageal varices and may function as an effective, non-invasive indicator for detecting high-risk cirrhotic patients. Integrating platelet count into clinical decision-making may enhance risk classification and refine endoscopic screening strategies in resource-constrained environments.