Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report.

RATIONALE: Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare.

PATIENT CONCERNS: A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus.

DIAGNOSIS: Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia.

INTERVENTIONS: Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy.

OUTCOMES: Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis.

LESSONS: Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.