The natural history of body-first versus brain-first Parkinson's disease subtypes.

BACKGROUND

Several lines of evidence support the hypothesis of brain-first and body-first Parkinson's disease (PD) subtypes, characterized by distinct origins of α-synuclein pathology. However, data on premotor non-motor burden and motor progression in these subtypes remain inconsistent.

OBJECTIVE

To analyze the natural history of body-first versus brain-first PD subtypes.

METHODS

Data from 400 PD patients enrolled at a single Italian center were analyzed. All patients underwent a standardized retrospective baseline assessment of premotor and motor symptoms at onset and were prospectively followed. Premotor REM sleep behavior disorder (RBD), considered a prodromal phenotype of the body-first subtype, was used to divide patients into two groups: 81 patients with probable premotor RBD (PDpreRBD+) and 319 patients without (PDpreRBD-).

RESULTS

At motor onset, PDpreRBD+ patients were older than PDpreRBD- patients, exhibited less tremor, and more frequently presented with bilateral motor symptoms. PDpreRBD+ patients also reported a greater burden of premotor symptoms, including hyposmia, cognitive impairment, pain, constipation, and other dysautonomic symptoms. Over the follow-up period, PDpreRBD+ patients progressed more rapidly to Hoehn and Yahr stage 3, even after adjusting for sex, years of schooling, age at motor onset, and initial motor phenotype.

CONCLUSIONS

Our results align with the hypothesis of brain-first and body-first PD subtypes, providing novel insights into their different premotor non-motor burden and motor progression trajectories.