[Monotherapy vs polypharmacy in psychiatry,practical aspects of monitoring plasma levels of psychotropic drugs].

This review examines the changing trends in antipsychotic therapy, with a particular focus on the use of combinations (the administration of multiple antipsychotic drugs simultaneously). In addition to investigating the prevalence of such practices, we discuss the pros and cons, as well as experiences with their application, based on lite rature data. The therapeutic drug monitoring, which is increasingly available in everyday clinical routines, is closely related to the use of combinations from a practical point of view. Analyzing current trends will likely provide guidance for optimizing our own clinical practice. Keywords: monotherapy; polypharmacy; therapeutic drug level monitoring.