European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020
Vaginal suppositories of cumin seeds essential oil for treatment of vaginal candidiasis: Formulation, in vitro, in vivo, and clinical evaluation.
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СтатьяОтозванная публикацияНазвание и аннотация: Перевод в очереди
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Abd Ellah Noura H, Shaltout Asmaa S, Abd El Aziz Shreen M M, Abbas Ahmed M, Abd El Moneem Hasnaa G, Youness Entisar M, Arief Amal F, Ali Marwa F, Abd El-Hamid Basma N
Аннотация
Fungal infections by resistant Candida species continue to be a significant health problem. Novel antifungal agents such as essential oils of cumin seeds (EOCS) are tested against vulvovaginal candidiasis (VVC). The aim of this study was to develop coated polyethylene glycol (PEG) vaginal suppositories containing EOCS for treatment of VVC. PEG suppositories containing EOCS were prepared ppearance, weight variation, drug content, hardness, dissolution time, release, stability and anticandida activity were evaluated. Biocompatibility of selected formulation was tested in female rabbits, followed by clinical evaluation. Coated suppositories showed complete release of the oil after 30 min, in vitro anti-candida activity, enhanced stability and sufficient safety on the vaginal tissues of rabbits. Clinical results showed significant lower rates of vaginal itching, discharge and dyspareunia combined with negative cultures in 70% of patients, revealing efficacy of EOCS-containing vaginal suppositories for treatment of VVC.