MedElevator
Войти в исследования American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
Maternal Neutrophil Inflammation Markers Predict Bronchopulmonary Dysplasia in Preeclamptic Pregnancies.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xie Tifeng, Hong Liping, Yi Ruiting, Cao Yuxiang, Wang Feiyang, Fan Siying, Li Yuan, Liu Tao, Liu Peiwen, Zhong Xinqi
Аннотация
PROBLEM: Preeclampsia (PE) and bronchopulmonary dysplasia (BPD) are severe disorders that significantly affect maternal and neonatal health worldwide. This study evaluated the predictive value of maternal hematologic indicators in PE patients for the risk of offspring BPD.
METHOD OF STUDY: A retrospective cohort study was conducted enrolling infants born before 34 weeks' gestation between September 2017 and December 2019 at the Third Affiliated Hospital of Guangzhou Medical University. Logistic regression analysis was used to evaluate the association between maternal hematologic indicators and offspring BPD. Subgroup analysis was performed to explore the interaction effects between maternal hematologic indicators and PE on neonatal BPD risk.
RESULTS: Data from 510 preterm infants and their mothers were analyzed. After adjusting for potential confounders, interaction effects between maternal white blood cell count (WBC), absolute neutrophil count (ANC), and PE on offspring BPD were observed (p for interaction <0.05). Among normotensive mothers, elevated WBC or ANC did not significantly increase the risk of offspring BPD (OR [95% CI]: 1.02 [0.93-1.12] for both). In contrast, in PE patients, higher levels of WBC and ANC were independently associated with offspring BPD risk (OR [95% CI]: 1.24 [1.06-1.47] and 1.22 [1.05-1.44], respectively). Moreover, WBC > 11.90 and NLR > 7.65 in PE patients were identified as independent predictors of neonatal BPD (OR [95% CI]: 4.88 [1.27-21.04] and 4.67 [1.41-17.27], respectively).
CONCLUSIONS: Neutrophil-related hematologic indicators, including WBC, ANC, and NLR in PE patients, are significantly and independently associated with the development of BPD. These findings highlight the potential of neutrophils as a promising focus for investigating the relationship between these maternal and neonatal disorders.
METHOD OF STUDY: A retrospective cohort study was conducted enrolling infants born before 34 weeks' gestation between September 2017 and December 2019 at the Third Affiliated Hospital of Guangzhou Medical University. Logistic regression analysis was used to evaluate the association between maternal hematologic indicators and offspring BPD. Subgroup analysis was performed to explore the interaction effects between maternal hematologic indicators and PE on neonatal BPD risk.
RESULTS: Data from 510 preterm infants and their mothers were analyzed. After adjusting for potential confounders, interaction effects between maternal white blood cell count (WBC), absolute neutrophil count (ANC), and PE on offspring BPD were observed (p for interaction <0.05). Among normotensive mothers, elevated WBC or ANC did not significantly increase the risk of offspring BPD (OR [95% CI]: 1.02 [0.93-1.12] for both). In contrast, in PE patients, higher levels of WBC and ANC were independently associated with offspring BPD risk (OR [95% CI]: 1.24 [1.06-1.47] and 1.22 [1.05-1.44], respectively). Moreover, WBC > 11.90 and NLR > 7.65 in PE patients were identified as independent predictors of neonatal BPD (OR [95% CI]: 4.88 [1.27-21.04] and 4.67 [1.41-17.27], respectively).
CONCLUSIONS: Neutrophil-related hematologic indicators, including WBC, ANC, and NLR in PE patients, are significantly and independently associated with the development of BPD. These findings highlight the potential of neutrophils as a promising focus for investigating the relationship between these maternal and neonatal disorders.