Rationally designed BTO@MSN@PPy-PEG piezoelectric nanozyme for ultrasound/NIR-triggered synergistic piezodynamic-photothermal-chemo tumor therapy.

Conventional monotherapies for tumors face significant challenges due to their limited therapeutic efficacy and considerable side effects, which severely impede their broad clinical application. To overcome the advancement of multimodal synergistic treatment strategies, integrating diverse treatment modalities with complementary mechanisms has emerged as a crucial approach to enhance the therapeutic outcomes of tumors. In this context, we developed a multifunctional nanoplatform, designated as BaTiO3@MSN@PPy-PEG Nanoparticles (BMPP NPs), which can be activated by a combination of ultrasound and near-infrared (NIR) laser irradiation. This nanoplatform is centered around the piezoelectric material barium titanate (BTO), employs a mesoporous silica (MSN) coating for efficient encapsulation of the chemotherapeutic agent curcumin (Cur), and is further modified with polypyrrole (PPy) and polyethylene glycol (PEG) to confer both excellent photothermal conversion capability and enhanced biocompatibility. The synergistic interplay among the ultrasound-induced piezoelectric effect, NIR laser-triggered photothermal therapy, and MSN-mediated drug release results in a novel triple-modal therapy-piezoelectric dynamic, photothermal, and chemo. This integrated strategy effectively suppresses tumor growth and facilitates tumor ablation, holding great promise for future cancer therapeutics.