[The diagnostic value of determination of tissue polypeptide specific antigen (TPS) in serum of women with breast cancer].

Studies were conducted in serum of 132 women. In 39 cases mastopathia fibrosocystica was diagnosed whereas the remaining 73 women had malignant breast cancer: 34-lobulare, 20-ductale and 19 of them-ductale and lobulare carcinoma. The concentration of tissue polypeptide specific antigen was determined by immunoenzymatic, BEKI DIAGNOSTIC test. The results showed, that TPS antigen concentration in serum of women without cancer symptoms was physiological, under 80 U/l. Whereas in 42 patients with benign neoplasm, in 5 of them the concentration of determined marker was over the cut-off. Our study showed, that the mediane of concentration of TPS antigen in serum of women with malignant neoplasm was over twice higher than in healthy women. The frequency of increased results and absolute value of TPS level showed trend to significant increase with the clinical progression of disease and grade of histological malignancy of neoplasm. The similar dependence of TPS concentration on metastasis number to lymph nodes was observed.