Zhonghua zhong liu za zhi [Chinese journal of oncology] · 1988
[Cytogenetic studies of lung cancer].
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Fang Y
Аннотация
Chromosome analysis was performed on tumor cells from 15 patients with lung cancer. The G-banding techniques were used for analysis of karyotypes. The results showed that numerical and structural abnormalities were found in each case. Chromosomal numbers varied in a range of 36-240. Aneuploids were present in 91.62% of all cells. The most common numerical alterations were subtriploidies and triploidies. Chromosomes 1, 11, 4, 5, and 3 were most frequently involved in 21 marker chromosomes. It was found that marker chromosomes M1, M3, M4 and M5 were related to chromosome 1 with the breakpoints assigned to 1p11, 1q11, 1p35 and an area of centromere. This result may suggest that breakpoint of chromosome 1 be related to the expression of oncogene of the lung cancer.