Pregnancy hypertension · 2013
PP074. Persistent proteinuria after a pre-eclamptic pregnancy.
СтатьяНазвание и аннотация: Перевод в очереди
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Roberts Anna, Green Amanda, Loughna Pamela, Broughton-Pipkin Fiona
Аннотация
INTRODUCTION: There is increasing evidence to suggest that both preeclampsia and microalbuminuria are linked to long term cardiovascular and renal disease [1,2].
OBJECTIVES: To identify the proportion and characteristics of women with persistent significant proteinuria at 6 weeks following delivery.
METHOD: We examined the blood pressure, serum electrolytes and urine protein creatinine ratio (PCR) in a cohort of 219 women who were seen following a pre-eclamptic pregnancy in a postnatal clinic at a minimum of 6 weeks following delivery.
RESULTS: A PCR>50mg/mmol (considered to be clinically significant) was seen in 4.1% women at 6 weeks after delivery. Women with a higher antenatal PCR were more likely to have a PCR>50mg/mmol at 6 weeks postnatal (p=0.003). Antenatal or postnatal blood pressure was not correlated with persistent significant proteinuria. Neither estimated nor calculated glomerular filtration rate (eGFR) at 6 weeks correlated with those having persistent proteinuria, however there was a trend towards lower eGFR and higher serum creatinine antenatally in this group (p=0.138 and p=0.088).
CONCLUSION: There are a small but worrying number of women who still have clinically significant proteinuria at 6 weeks after a pre-eclamptic pregnancy. This represents a group of women who may have a higher risk of cardiovascular and renal disease.
OBJECTIVES: To identify the proportion and characteristics of women with persistent significant proteinuria at 6 weeks following delivery.
METHOD: We examined the blood pressure, serum electrolytes and urine protein creatinine ratio (PCR) in a cohort of 219 women who were seen following a pre-eclamptic pregnancy in a postnatal clinic at a minimum of 6 weeks following delivery.
RESULTS: A PCR>50mg/mmol (considered to be clinically significant) was seen in 4.1% women at 6 weeks after delivery. Women with a higher antenatal PCR were more likely to have a PCR>50mg/mmol at 6 weeks postnatal (p=0.003). Antenatal or postnatal blood pressure was not correlated with persistent significant proteinuria. Neither estimated nor calculated glomerular filtration rate (eGFR) at 6 weeks correlated with those having persistent proteinuria, however there was a trend towards lower eGFR and higher serum creatinine antenatally in this group (p=0.138 and p=0.088).
CONCLUSION: There are a small but worrying number of women who still have clinically significant proteinuria at 6 weeks after a pre-eclamptic pregnancy. This represents a group of women who may have a higher risk of cardiovascular and renal disease.