FEBS letters · 2008
Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ohinata Kousaku, Fujiwara Yoko, Fukumoto Shingo, Iwai Masaru, Horiuchi Masatsugu, Yoshikawa Masaaki
Аннотация
Intracerebroventricularly administered angiotensin (Ang) II and III dose-dependently suppressed food intake in mice and their anorexigenic activities were inhibited by AT(2) receptor-selective antagonist. Ang II did not suppress food intake in AT(2) receptor-knockout mice, while it did significantly in wild-type and AT(1) receptor-knockout mice. The suppression of food intake in AT(1) receptor-knockout mice was smaller than that in wild-type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP(4) receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT(2) receptor with partial involvement of AT(1) receptor, followed by EP(4) receptor activation, which is a novel pathway regulating food intake.
Предметные рубрики MeSH
Angiotensin IIAngiotensin II Type 1 Receptor BlockersAngiotensin II Type 2 Receptor BlockersAngiotensin IIIAnimalsAppetite DepressantsCentral Nervous SystemFastingFeeding BehaviorInjections, IntraventricularMaleMiceMice, Inbred C57BLReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Receptors, Prostaglandin EReceptors, Prostaglandin E, EP4 Subtype