Recent advances in the synthesis of N-acyl sulfonamides.

The N-acyl sulfonamide group is widespread in pharmaceutically active compounds. This is partly due to the ability of N-acyl sulfonamides to act as bioisosteric equivalents of carboxylic acids. Accordingly, methods for the efficient preparation of N-acyl sulfonamides are of considerable interest to medicinal chemists. In this review, we summarise developments in the synthesis of this pharmaceutically relevant functional group across a broad range of methodologies.