The management and natural history of severe dysplasia and carcinoma in situ of the uterine cervix.

This report concerns 375 patients seen in Frederiksberg, Denmark, between 1951 and 1972: 103 of them had severe dysplasia and 272 of them carcinoma in situ of the uterine cervix. Thirty patients had no primary treatment: 9 of them developed invasive carcinoma, and 2 of these died; 12 patients had persistent intraepithelial abnormality of the cervix and the other 9 patients showed no abnormality after varying periods of observation. Recurrences after cone biopsy were noted in 9.5 and 10.1 per cent of patients with severe dysplasia and carcinoma in situ respectively, and in 2 per cent of patients who had an in situ carcinoma treated by hysterectomy. This made a total of 15 patients with recurrences. All were ultimately cured although two patients were found to have invasive carcinoma.