[Serum sex hormone and urinary metabolites of male workers exposed to carbon disulfide].

Serum luteotropic hormone(LH), follicle-stimulating hormone (FSH), prolectin(PRL) and testosterone (T) were determined by radioimmunoassay methods in 50 workers exposed to carbon disulfide(CS2) in a viscose rayon factory. Urinary excretion of 2-thio-thiazolidine-4-carboxilic acid (TTCA) in workers by the end of work shift was analyzed with modified high-performance liquid chromatography. The working conditions of the factory had not been changed since 1950s. The concentration of CS2, determined by Multigas Monitor (type 1320) in workplace, was (14.4 +/- 4.62) mg/m3. The results showed that: (1) serum FSH of CS2 group (10.04 +/- 7.35)IU/L was significantly higher than that of control group (7.50 +/- 7.07 IU/L), PRL of CS2 group (5.72 +/- 4.18) ng/L was significantly lower than that of control group (6.89 +/- 4.64 ng/L). Serum LH was declined with the increase of time exposed to CS2, (2) urinary TTCA in CS2 group was 1.072 +/- 1.013 mg/g Cr. Serum FSH was declined with the increase of TTCA excretion. The results suggested that the function of endocrine system was disturbed in workers exposed to CS2.