[Yellow body function in bromocryptine induced early pregnancy in patients with hyperprolactinemia (author's transl)].

In six patients estrogens and gonadotropins were low and the prolactin concentration was increased (36-128 micrograms/l). Amenorrhea in all patients lasted 8-60 months, while galactorrhea was observed in five patients. By the X-ray of the sella turcica and neurologic and ophthalmologic examinations no signs of an intrasellar expansive process were revealed. The progesterone test was negative in four patients and the clomiphene test in all six patients. The LH-RH test (100 micrograms i. m.) showed the increased LH and FSH concentrations in all six patients. They all became pregnant in the course of the bromocryptine treatment (5-7.5 mg daily). Pregnanediol and prolactin concentrations were recorded every 14 days in the first 16 weeks of pregnancy, both in six patients and in eleven controls with spontaneous pregnancy. The pregnanediol concentrations proved somewhat higher in the control group than in patients having become pregnant under the bromocryptine therapy, but the differences are not statistically significant. However, the prolactin concentrations were significantly lower in controls than in pregnant women with the hyperprolactinemic anovulatory syndrome (p less than 0.01) in the sixth to the twelfth week of pregnancy.