Effects of crush and devascularizing injuries to the proximal ureter. An experimental study.

Crush and devascularizing injuries were performed on proximal canine ureters. The pathogenesis of the reaction to these injuries was evaluated by using microbiologic, physiologic, radiologic, biophysical, histologic, and anatomic techniques. The results indicated that within 12 weeks after crush injuries lasting up to 60 min, renal function fully returned and radiologic demonstration of the crush area resolved, even through other radiologic and pathologic changes persisted in hte crushed ureters. The pathophsiologic results of devascularizing injuries that did not resolve spontaneously tended to progress more rapidly and case more serious renal impairment than any of the crush injuries. Devascularizing injuries that resolved tended to be benign in their effect.