Current clinical spectrum of neurosyphilis in immunocompetent patients.

BACKGROUND

Neurosyphilis (NS) is nowadays a less frequent disease. Its incidence and clinical spectrum have changed over time.

OBJECTIVE

To estimate the incidence of NS and describe the clinical spectrum of NS in immunocompetent patients in the last decade.

METHODS

Demographic and clinical features, cerebrospinal fluid (CSF) changes, neuroimaging findings and outcome were retrospectively analyzed.

RESULTS

Forty-three patients met NS criteria. The yearly incidence was 0.2- 2.1 cases per 100,000 inhabitants. The mean age was 48.1 years, males being more frequently involved. The most frequent clinical patterns were meningovascular (30.2%), meningeal (25.6%) and general paresis (25.6%). Compared to prepenicillin series, we observed a decrease in late forms, mainly tabes dorsalis. CSF titers studied by the Venereal Disease Research Laboratory were higher in early NS. Neuroimaging findings were nonspecific. Outcome was better for early forms.

CONCLUSIONS

Compared to the preantibiotic era, a lower frequency of late NS was observed, similar to that reported in other modern series which include patients with HIV infection. Therefore, this trend seems to be due to the impact of antibiotics rather than to HIV infection.