Immunoglobulin M/Immunoglobulin A-Enriched Immunoglobulins: A Key to Breaking the Cycle of Clostridioides difficile Infection Recurrences in Patients With Hypogammaglobulinemia?

We present the case of a 57-year-old woman with secondary hypogammaglobulinemia who experienced Clostridioides difficile infection (CDI), with repeated recurrences despite transient clinical responses to standard therapies, including repeated fecal microbiota transplantation. Following the replacement of intravenous immunoglobulin supplementation with immunoglobulin M/immunoglobulin A-enriched immunoglobulin, no recurrence of CDI was observed during the 24-month follow-up period.