Journal of stomatology, oral and maxillofacial surgery · 2026
Malignant-transformation-free survival in oral potentially malignant disorders in the State of Espírito Santo, Brazil.
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Ribeiro Beatriz, Marinato Ana Luísa Zonzini, Deps Tahyna Duda, Silva Daniela Nascimento, Sulti Amanda Del Caro, Cardoso Orlei Amaral, Dell'Antonio Larissa Soares, Pimenta-Barros Liliana Aparecida, Camisasca Danielle Resende
Аннотация
OBJECTIVE: To evaluate malignant-transformation-free survival (MTFS) in patients with oral potentially malignant disorders (OPMDs).
MATERIAL AND METHODS: A 11-year long retrospective cohort study was conducted at a public Oral Pathology Service and patients diagnosed either with oral lichen planus, oral lichenoid lesion, oral leukoplakia (OL), proliferative verrucous leukoplakia (PVL), or erythroplakia were included. Head and neck squamous cell carcinoma diagnosis was assessed through cross-referencing patient records with the State Health Department Cancer Registry. Kaplan-Meier curves were used to evaluate malignant-transformation-free survival.
RESULTS: A total of 197 OPMDs were included, malignant transformation occurred in 11 (5.6%) cases, with PVL showing the highest rate (n=6, 54.5%). OL was the most frequent diagnosis (n=95, 48.2%) and most OPMD cases with malignant transformation showed epithelial dysplasia at baseline. MTFS rates were 98.5% (1 year), 97.5% (3 years), and 95.9% (5 years).
CONCLUSIONS: Continuous monitoring of OPMD patients is crucial for early detection of malignization, but MTFS was high for OPMDs.
MATERIAL AND METHODS: A 11-year long retrospective cohort study was conducted at a public Oral Pathology Service and patients diagnosed either with oral lichen planus, oral lichenoid lesion, oral leukoplakia (OL), proliferative verrucous leukoplakia (PVL), or erythroplakia were included. Head and neck squamous cell carcinoma diagnosis was assessed through cross-referencing patient records with the State Health Department Cancer Registry. Kaplan-Meier curves were used to evaluate malignant-transformation-free survival.
RESULTS: A total of 197 OPMDs were included, malignant transformation occurred in 11 (5.6%) cases, with PVL showing the highest rate (n=6, 54.5%). OL was the most frequent diagnosis (n=95, 48.2%) and most OPMD cases with malignant transformation showed epithelial dysplasia at baseline. MTFS rates were 98.5% (1 year), 97.5% (3 years), and 95.9% (5 years).
CONCLUSIONS: Continuous monitoring of OPMD patients is crucial for early detection of malignization, but MTFS was high for OPMDs.