Медицинская библиотека · Acta anaesthesiologica Scandinavica · 2026

Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE).

Crone Vera, Møller Morten Hylander, Granholm Anders, Perner Anders, Alhazzani Waleed, Krogsgaard Laura Rindom, Al-Fares Abdulrahman, Hästbacka Johanna, Ostermann Marlies, Pfortmueller Carmen A, Ferrer Ricard, Blaser Annika Reintam, Wall Olof, Keus Eric, Szczeklik Wojciech, Hansen Peter Martin, Michelsen Jens, Bak Mikkel, Balkert Lise Skyttegaard, Severinsen Tino, Brøchner Anne Craveiro, Pedersen Jonas Elmer, Andreasen Anne Sofie, Nielsen Camilla Tageby, Itenov Theis Skovsgaard, Kjær Maj-Brit Nørregaard, Engbakken Zemira, Bestle Morten Heiberg, Hjortrup Peter Buhl, Svendsen Christian Juhl, Lindkvist-Viggers Sandra, Brand Björn Anders, Jonsson Andreas Bender, Krogh Tobias Browall, Jauho Kristian Reinhold, Thomsen Mathias Sinkbæk, Straarup Therese Simonsen, Poulsen Eva, Nissen Christian Gade, Breum Olena, Petersen Per Lund, Torp Christopher, Rasmussen Bodil Steen, Bunzel Anne-Marie Gellert, Buholzer Seraina-Flavia, Hardman Elizabeth, Törnberg Daniel, Pérez David S, van Smaalen Kenneth, Onrust Marisa, Maddison Liivi, Appelberg Oskar, Ehrlich Hans-Erik, Tamme Kadri, Juhanson Reile, Korjas Jaanus, Jalkanen Ville, Finni Marleena, Reinikainen Matti, Koskue Talvikki, Czok Marcelina, Zatorski Pawel, Doroba Oliwia, Kudlinski Bartosz, Nowak Pawel, Bialka Szymon, Kluzik Anna, Baran Hanna, Al Duhailib Zainab, Hakeam Hakeam A, Alshahrani Mohammed, Elfaki Osama Ahmed, Alanazi Fadah A, Aldhahri Rakan, Belkhouja Khairallah, Alahmari Ali, Alsayer Rawabi M, Friman Ola, Balintescu Anca, Krag Mette

СтатьяМногоцентровое исследованиеПеревод в очереди

Аннотация

BACKGROUND

Feeding intolerance is common in intensive care unit (ICU) patients, but evidence supporting prokinetic use is limited. We aimed to provide international epidemiological data on the use of prokinetic agents in adult ICU patients and to explore potential associations with patient-important outcomes.

METHODS

We conducted an inception cohort study between August 2024 and March 2025 in acutely admitted ICU patients in 56 ICUs across 11 countries. The primary outcome was the proportion of patients receiving prokinetic agents. Secondary outcomes included associations with baseline characteristics, serious adverse events (SAEs), days alive out of ICU/hospital, days alive without life support and 90-day mortality. Associations with SAEs, baseline characteristics and mortality were assessed using pre-specified Cox regression models, while other secondary outcomes were evaluated using adjusted linear regression. All models were adjusted for country, severity of illness, number of comorbidities, surgery and ICU admission type.

RESULTS

Among 1440 ICU patients (median age 64 years, 56.9% male), 187 (13.0%; 95% confidence interval [CI] 11.3-14.8) received prokinetic agents during ICU stay, most commonly metoclopramide (65%). Prior abdominal surgery was associated with the initiation of prokinetic agents (hazard ratio [HR] 1.81; 95% CI 1.17-2.79). Use of prokinetic agents was statistically significantly associated with a higher hazard of experiencing a SAE (HR 1.9; 95% CI 1.3-2.8), fewer days alive out of ICU (mean difference [MD] -7.6 days; 95% CI, -13.4 to -2.2) and hospital (-13.5 days; 95% CI -18.7 to -8.4), but not with 90-day mortality (HR 0.62; 95% CI 0.3-1.2).

CONCLUSIONS

Prokinetic agents were used in 13% of ICU patients, most commonly metoclopramide and more often in those with prior abdominal surgery. Prokinetic use was associated with a higher hazard of experiencing SAEs and fewer days alive out of hospital/ICU.

Для цитирования: Crone Vera, Møller Morten Hylander, Granholm Anders, Perner Anders, Alhazzani Waleed, Krogsgaard Laura Rindom, Al-Fares Abdulrahman, Hästbacka Johanna, Ostermann Marlies, Pfortmueller Carmen A, Ferrer Ricard, Blaser Annika Reintam, Wall Olof, Keus Eric, Szczeklik Wojciech, Hansen Peter Martin, Michelsen Jens, Bak Mikkel, Balkert Lise Skyttegaard, Severinsen Tino, Brøchner Anne Craveiro, Pedersen Jonas Elmer, Andreasen Anne Sofie, Nielsen Camilla Tageby, Itenov Theis Skovsgaard, Kjær Maj-Brit Nørregaard, Engbakken Zemira, Bestle Morten Heiberg, Hjortrup Peter Buhl, Svendsen Christian Juhl, Lindkvist-Viggers Sandra, Brand Björn Anders, Jonsson Andreas Bender, Krogh Tobias Browall, Jauho Kristian Reinhold, Thomsen Mathias Sinkbæk, Straarup Therese Simonsen, Poulsen Eva, Nissen Christian Gade, Breum Olena, Petersen Per Lund, Torp Christopher, Rasmussen Bodil Steen, Bunzel Anne-Marie Gellert, Buholzer Seraina-Flavia, Hardman Elizabeth, Törnberg Daniel, Pérez David S, van Smaalen Kenneth, Onrust Marisa, Maddison Liivi, Appelberg Oskar, Ehrlich Hans-Erik, Tamme Kadri, Juhanson Reile, Korjas Jaanus, Jalkanen Ville, Finni Marleena, Reinikainen Matti, Koskue Talvikki, Czok Marcelina, Zatorski Pawel, Doroba Oliwia, Kudlinski Bartosz, Nowak Pawel, Bialka Szymon, Kluzik Anna, Baran Hanna, Al Duhailib Zainab, Hakeam Hakeam A, Alshahrani Mohammed, Elfaki Osama Ahmed, Alanazi Fadah A, Aldhahri Rakan, Belkhouja Khairallah, Alahmari Ali, Alsayer Rawabi M, Friman Ola, Balintescu Anca, Krag Mette. Use of Prokinetic Agents in Adult ICU Patients: An International Inception Cohort Study (PATIENCE).. Acta anaesthesiologica Scandinavica. 2026. DOI: 10.1111/aas.70290.

Предметные рубрики MeSH

Humans Intensive Care Units Female Middle Aged Male Cohort Studies Aged Gastrointestinal Agents Metoclopramide Critical Care

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