Pakistan journal of pharmaceutical sciences · 2026
Protective effects of Xiaoshi Lipi formula on gastric precancerous lesions via multi-target regulation of inflammation, oxidative stress, ferroptosis and apoptosis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lu Xiaomin, Zhou Meihua, Dong Mingguo, Hong Zhongyuan, Guo Wansha, Wang Yuxin, Yuan Ruixing
Аннотация
BACKGROUND: Xiaoshi Lipi formula, a traditional Chinese medicine, may alleviate Gastric precancerous lesion (GPL) progression through multi-target mechanisms.
OBJECTIVES: To evaluate the protective effects of Xiaoshi Lipi formula on GPL and its underlying mechanisms.
METHODS: GPL was induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium deoxycholate. Animals were assigned to normal, model, positive control and low-, medium-, or high-dose Xiaoshi Lipi formula groups. Gastric pathology was assessed by HE and AB-PAS staining. Serum inflammatory cytokines (TNF-α, IL-6, IL-1β), gastric function markers (G-17, PG I, PG II, PGE2), oxidative stress indices (ROS, MDA, SOD, GSH), ferroptosis- and antioxidant-related proteins and apoptosis (TUNEL) were analyzed.
RESULTS: Xiaoshi Lipi formula markedly alleviated gastric mucosal atrophy and intestinal metaplasia and improved gastric function. In the medium-dose group, G-17, PG I and PGE2 increased by ~90%, 70% and 62%, respectively, while PGⅡ decreased by ~40%. TNF-α, IL-6 and IL-1β were reduced by ~45%. ROS and MDA declined by ~48% and 50%, while SOD and GSH rose by ~38% and 83%. GPX4 and SLC7A11 were restored, Nrf2/HO-1 pathway activated and TUNEL-positive cells reduced by ~68%. Medium-dose effects were comparable to the positive control.
CONCLUSION: Xiaoshi Lipi formula ameliorates GPL by targeting inflammation, oxidative stress and ferroptosis, supporting its potential in gastric cancer prevention.
OBJECTIVES: To evaluate the protective effects of Xiaoshi Lipi formula on GPL and its underlying mechanisms.
METHODS: GPL was induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium deoxycholate. Animals were assigned to normal, model, positive control and low-, medium-, or high-dose Xiaoshi Lipi formula groups. Gastric pathology was assessed by HE and AB-PAS staining. Serum inflammatory cytokines (TNF-α, IL-6, IL-1β), gastric function markers (G-17, PG I, PG II, PGE2), oxidative stress indices (ROS, MDA, SOD, GSH), ferroptosis- and antioxidant-related proteins and apoptosis (TUNEL) were analyzed.
RESULTS: Xiaoshi Lipi formula markedly alleviated gastric mucosal atrophy and intestinal metaplasia and improved gastric function. In the medium-dose group, G-17, PG I and PGE2 increased by ~90%, 70% and 62%, respectively, while PGⅡ decreased by ~40%. TNF-α, IL-6 and IL-1β were reduced by ~45%. ROS and MDA declined by ~48% and 50%, while SOD and GSH rose by ~38% and 83%. GPX4 and SLC7A11 were restored, Nrf2/HO-1 pathway activated and TUNEL-positive cells reduced by ~68%. Medium-dose effects were comparable to the positive control.
CONCLUSION: Xiaoshi Lipi formula ameliorates GPL by targeting inflammation, oxidative stress and ferroptosis, supporting its potential in gastric cancer prevention.