Secondary Syphilis: a Histopathological Study.

The histopathological patterns were studied in 44 biopsies from 31 cases of secondary syphilis. The classical picture of syphilis was observed in majority of the cases, but it was lacking or inconspicuous in 22.72% cases. Granulomatous reaction was observed in 15.9% cases during early stage of the disease. Epidermal changes like hyporkeratosis, parakeratosis, exocytosis, spongiosis and acanthosis were frequently seen. Keratotic plugging was observed in 11.36%, hypergranulosis in 2.27% cases and basal cell degeneration in 33.63% cases.