Impact of leisure-time and daily life physical activity on chronic kidney disease in individuals with type 2 diabetes: The Fukuoka Diabetes Registry.

BACKGROUND

The beneficial effects of physical activity (PA) on cardiovascular disease and its risk factors have been well established. However, evidence linking PA to chronic kidney disease (CKD) in patients with diabetes is limited. This study aimed to examine the association between PA, including leisure-time PA (LTPA) and daily life PA (DLPA), and CKD cross-sectionally.

METHODS

A total of 4,922 patients with type 2 diabetes were classified into quartiles of LTPA and three categories of DLPA (sedentary, light, and moderate/vigorous). CKD was defined as a decreased estimated glomerular filtration rate (eGFR) based on cystatin C (< 60 mL/min/1.73 m2) and/or albuminuria (urinary albumin-to-creatinine ratio ≥ 30 mg/g). Odds ratios for the presence of CKD were computed using logistic regression analyses.

RESULTS

Higher LTPA levels were significantly associated with a lower likelihood of developing CKD (P for trend = 0.001). Higher DLPA was also associated with a lower prevalence of CKD (P for trend < 0.001). Similar associations were observed for decreased eGFR and albuminuria. The combination of higher LTPA and DLPA levels further decreased the likelihood of CKD, with a significant interaction between the two.

CONCLUSIONS

Higher LTPA and DLPA levels were independently associated with a lower prevalence of CKD in patients with type 2 diabetes.