Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
Association of epiretinal membranes with disability in people with multiple sclerosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Lin Ting-Yi, Bacchetti Anna, McCormack Brenna, Moussa Hussein, Krett Jonathan D, Ezzedin Omar, Otero-Duran Gabriel, Pellegrini Nicole, Inserra Madeline, Newsome Scott D, Nourbakhsh Bardia, Fitzgerald Kathryn C, Sotirchos Elias S, Calabresi Peter A, Kashani Amir H, Saidha Shiv
Аннотация
BACKGROUND: Epiretinal membranes (ERMs) consist of glial and fibrocellular tissue, potentially arising from pathologic microgliosis, macrogliosis, and/or retinal pigment epithelium (RPE) cell migration. The clinical relevance of ERMs in people with multiple sclerosis (PwMS) remains largely unstudied.
OBJECTIVES: To investigate ERM prevalence and their associations with retinal layer thicknesses and disability measures in PwMS.
METHODS: PwMS exhibiting ERMs (ERM+) were matched 1:1 with PwMS without ERMs (ERM-) by optic neuritis (ON) history, multiple sclerosis (MS) subtype, age, sex, and race. Disability assessments included high-contrast/low-contrast letter acuity (HC-/LCLA), Expanded Disability Status Scale (EDSS), walking speed test (WST), manual dexterity test (MDT), and processing speed test (PST) scores.
RESULTS: Among 1264 participants screened (1120 PwMS and 144 healthy controls [HCs]), ERMs were observed in 206 PwMS (18.4%) and 17 HCs (11.8%). ERM+ PwMS exhibited higher EDSS (1.0 ± 0.3, p = 0.002), longer WST (0.8 ± 0.2 seconds, p < 0.001), longer MDT (2.2 ± 0.5 seconds, p < 0.001), lower PST (-3.0 ± 1.4, p = 0.08), lower LCLA (-4.2 ± 1.1 letters, p < 0.001), and lower ganglion cell-inner plexiform layer (-1.8 ± 0.8 µm, p = 0.03), inner nuclear layer (-0.8 ± 0.3 µm, p = 0.01), outer nuclear layer (-1.6 ± 0.6 µm, p = 0.01), and RPE (-0.5 ± 0.1 µm, p < 0.001) thicknesses. Higher ERM stage correlated with greater disability.
CONCLUSION: ERMs may identify a distinct MS phenotype, potentially characterized by pathological microglial and/or macroglial activity. ERMs may be a marker of similar global processes throughout the central nervous system that potentially contribute to greater overall disability.
OBJECTIVES: To investigate ERM prevalence and their associations with retinal layer thicknesses and disability measures in PwMS.
METHODS: PwMS exhibiting ERMs (ERM+) were matched 1:1 with PwMS without ERMs (ERM-) by optic neuritis (ON) history, multiple sclerosis (MS) subtype, age, sex, and race. Disability assessments included high-contrast/low-contrast letter acuity (HC-/LCLA), Expanded Disability Status Scale (EDSS), walking speed test (WST), manual dexterity test (MDT), and processing speed test (PST) scores.
RESULTS: Among 1264 participants screened (1120 PwMS and 144 healthy controls [HCs]), ERMs were observed in 206 PwMS (18.4%) and 17 HCs (11.8%). ERM+ PwMS exhibited higher EDSS (1.0 ± 0.3, p = 0.002), longer WST (0.8 ± 0.2 seconds, p < 0.001), longer MDT (2.2 ± 0.5 seconds, p < 0.001), lower PST (-3.0 ± 1.4, p = 0.08), lower LCLA (-4.2 ± 1.1 letters, p < 0.001), and lower ganglion cell-inner plexiform layer (-1.8 ± 0.8 µm, p = 0.03), inner nuclear layer (-0.8 ± 0.3 µm, p = 0.01), outer nuclear layer (-1.6 ± 0.6 µm, p = 0.01), and RPE (-0.5 ± 0.1 µm, p < 0.001) thicknesses. Higher ERM stage correlated with greater disability.
CONCLUSION: ERMs may identify a distinct MS phenotype, potentially characterized by pathological microglial and/or macroglial activity. ERMs may be a marker of similar global processes throughout the central nervous system that potentially contribute to greater overall disability.