Fertility and sterility · 2016
Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births.
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Kettner Laura Ozer, Matthiesen Niels Bjerregaard, Ramlau-Hansen Cecilia Høst, Kesmodel Ulrik Schiøler, Bay Bjørn, Henriksen Tine Brink
Аннотация
OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.
DESIGN: Nationwide birth cohort study.
SETTING: Not applicable.
PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.
RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.
CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.
DESIGN: Nationwide birth cohort study.
SETTING: Not applicable.
PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.
RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.
CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.
Предметные рубрики MeSH
AdultAge of OnsetCohort StudiesDenmarkDiabetes Mellitus, Type 1FemaleFertilityFertility Agents, FemaleFertilization in VitroFollicle Stimulating HormoneHumansHypoglycemic AgentsInfertilityInsemination, ArtificialInsulinLive BirthMaleOvulation InductionPregnancyRegistriesReproductive Techniques, AssistedRisk AssessmentRisk FactorsSperm Injections, IntracytoplasmicTime FactorsTreatment Outcome