Candida parapsilosis Oral Infection in an HIV-Negative Infant With Profound CD4+ Lymphopenia: Unveiling a Rare Immunodeficiency Scenario.

We describe a rare pediatric case of severe oral candidiasis caused by Candida parapsilosis (C. parapsilosis), associated with significant CD4+ lymphopenia and negative HIV serology. A previously healthy six-year-old female presented with high-grade fever and refractory oral lesions. Laboratory investigations revealed profound CD4+ lymphopenia and negative HIV serology. Treatment with intravenous fluconazole resulted in rapid clinical improvement. This report underscores the importance of early immunological evaluation and genetic investigation in pediatric patients with atypical oral candidiasis.