Corneal Sealants in Pre-Clinical Development.

PURPOSE: To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.

METHOD: A systematic review of major databases from inception to 4th March 2025.

RESULTS

Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.

CONCLUSION

A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.