Comparative Study of Carbapenemase Inhibitor and NG-Test CARBA5 for the Detection of Carbapenemase of Enterobacteriaceae.

BACKGROUND

This study aimed to evaluate the application of carbapenemase inhibitor and NG-test CARBA5 in the detection of carbapenemase genotype for Enterobacteriaceae.

METHODS

We collected non-repetitive CRE (carbapenem-resistant Enterobacterales) isolated from patients at the Affiliated Cancer Hospital of Zhengzhou University in 2022. The carbapenemase type and gene type were detected by carbapenemase inhibitor test and NG-test CARBA5 assay, respectively.

RESULTS

Sensitivity and specificity of the carbapenemase inhibitor test detecting five common carbapenemases were 100.00% and 98.36%, respectively. Sensitivity and specificity of NG-test CARBA5 were 95.90% and 99.18%, respectively.

CONCLUSIONS

The carbapenemase inhibitor test and NG-test CARBA5 showed high sensitivity and specificity in detecting carbapenemase of Enterobacteriaceae.