Electrochemically Promoted Three-Component Synthesis for the Functionalization of N-Sulfonylformamidine.

A one-pot synthetic strategy was developed by using electrochemical methods to convert sulfonamides into N-sulfonylformamidines, followed by the direct functionalization of the C-H bond through Shono oxidation. Subsequently, modification was achieved by introducing azide groups via imide ions under Lewis acid catalysis, utilizing TMSN3 as the nucleophilic reagent. This strategy is compatible with a wide range of functional groups, and its utility has been demonstrated through scale-up experiments and derivatization reactions.