Parkinson's disease tremor prediction towards real-time suppression: A self-attention deep temporal convolutional network approach.

Accurate prediction of Parkinson's disease tremor (PDT) is crucial for developing assistive technologies; however, this is challenging due to the nonlinear, stochastic, and nonstationary characteristics of PDT, which substantially vary among patients and their activities. Moreover, most models only have one-step prediction capabilities, which causes delays in real-time applications. This paper proposes a self-attention deep temporal convolutional network (SADTCN) model for the real-time prediction of hand-arm PDT signals from different activities and joint angular motions. The SADTCN can capture both short- and long-term dependencies and complex temporal and spatial dynamics of PDT signals and hence, can effectively adapt to varying tremor characteristics. The performance of the proposed model is evaluated using experimental hand-arm PDT data. The results show that the SADTCN outperforms existing deep learning (DL) models by accurately predicting varying tremor amplitudes and frequencies multi-step ahead. Moreover, we performed spectrum analysis on the measured and predicted signal using the short-time Fourier transform (STFT) as a measure of potential active tremor control and found that SADTCN can accurately determine the transience of tremor amplitude in frequency and time. Finally, we run the Wilcoxon signed-rank statistical test and the results show a statistically significant improvement in the proposed model over the other DL models in all conditions. Therefore, the SADTCN can overcome the nonstationary, nonlinear, and stochastic nature of PDT to perform multi-step prediction with high accuracy, robustness, and generalizability in unseen testing data.