The oncologist · 2026
Novel genomic score predicts survival with immune checkpoint inhibition in neuroendocrine neoplasms.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brar Tanvi, Olowookere Charles, Le Dat, Xu Menglin, Konda Bhavana, Sukrithan Vineeth
Аннотация
BACKGROUND: Immune checkpoint inhibition (ICI) has activity in Grade 3 (G3) neuroendocrine neoplasms (NENs), but predictive biomarkers of long-term overall survival (OS) are currently lacking.
METHODS: We derived a genomic scoring system using a retrospective cohort of 54 NEN patients treated with nivolumab and/or ipilimumab, alongside a chemotherapy-only control (n = 15) and pan-cancer validation cohort (n = 1661). An overall genomic score (GS-O) combining positive (GS-P) and negative response genes (GS-N) was calculated.
RESULTS: In the ICI cohort, patients with GS-O ≥ 2 had significantly better outcomes: median OS was not reached, compared to 3.9 months for low scores (HR = 0.007, P < .001). After multivariate adjustment, GS-P was independently associated with improved OS while GS-N showed a trend towards worsened OS. Importantly, GS-O ≥ 2 did not predict survival in the chemotherapy-alone cohort but was validated as independently predictive in the pan-cancer validation dataset (HR = 0.92, P < .001).
CONCLUSION: This study establishes a novel genomic score to predict OS in NENs treated with ICI with important pan-cancer implications.
METHODS: We derived a genomic scoring system using a retrospective cohort of 54 NEN patients treated with nivolumab and/or ipilimumab, alongside a chemotherapy-only control (n = 15) and pan-cancer validation cohort (n = 1661). An overall genomic score (GS-O) combining positive (GS-P) and negative response genes (GS-N) was calculated.
RESULTS: In the ICI cohort, patients with GS-O ≥ 2 had significantly better outcomes: median OS was not reached, compared to 3.9 months for low scores (HR = 0.007, P < .001). After multivariate adjustment, GS-P was independently associated with improved OS while GS-N showed a trend towards worsened OS. Importantly, GS-O ≥ 2 did not predict survival in the chemotherapy-alone cohort but was validated as independently predictive in the pan-cancer validation dataset (HR = 0.92, P < .001).
CONCLUSION: This study establishes a novel genomic score to predict OS in NENs treated with ICI with important pan-cancer implications.