Clinical and experimental nephrology · 2026
Effects of low-phosphate boiled-meat meal on CKD-MBD and inflammatory indicators in maintenance hemodialysis patients with controlled calcium carbonate dosing.
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Chen Barbara Ying-Jung, Wu Mei-Yi, Chin Mei-Yun, Wu Mai-Szu, Chen Jiun-Rong
Аннотация
BACKGROUND: This study investigated whether low-phosphate boiled-meat meals (LP meals), provided together with a fixed minimal dose of calcium carbonate (CaCO3), could help maintain stable CKD-MBD and inflammatory indicators in maintenance hemodialysis (MHD) patients, compared with standard meals receiving the same CaCO3 dose.
METHODS: Participants completed an adaptation diet followed by 7 days of LP meals or standard control meals. Both groups received an identical minimal dose of CaCO3 (1 tablet/meal) to ensure equivalent binder exposure. Blood CKD-MBD parameters, inflammatory markers, and dietary intake were assessed at baseline and after the intervention.
RESULTS: Forty patients completed the study (LP group, n = 20; control group, n = 20). Serum phosphate levels increased significantly in the control group after the intervention but remained stable in the LP group (2nd 6.61 ± 2.04 mg/dL vs. 1st 5.61 ± 1.14 mg/dL; P < 0.05). Reductions in tumor necrosis factor-α and serum calcium from baseline were significantly greater in the LP group than in the control group (both P < 0.05).
CONCLUSION: The LP meals, when consumed with a controlled, minimal CaCO3 dose, helped prevent increases in blood phosphate, hypercalcemia, and inflammation compared with standard meals that received the same binder dose.
METHODS: Participants completed an adaptation diet followed by 7 days of LP meals or standard control meals. Both groups received an identical minimal dose of CaCO3 (1 tablet/meal) to ensure equivalent binder exposure. Blood CKD-MBD parameters, inflammatory markers, and dietary intake were assessed at baseline and after the intervention.
RESULTS: Forty patients completed the study (LP group, n = 20; control group, n = 20). Serum phosphate levels increased significantly in the control group after the intervention but remained stable in the LP group (2nd 6.61 ± 2.04 mg/dL vs. 1st 5.61 ± 1.14 mg/dL; P < 0.05). Reductions in tumor necrosis factor-α and serum calcium from baseline were significantly greater in the LP group than in the control group (both P < 0.05).
CONCLUSION: The LP meals, when consumed with a controlled, minimal CaCO3 dose, helped prevent increases in blood phosphate, hypercalcemia, and inflammation compared with standard meals that received the same binder dose.