Fertility and sterility · 2003
Monozygotic twins discordant for vaginal agenesis and bilateral tibial longitudinal deficiency.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Steinkampf Michael P, Dharia Sejal P, Dickerson Ryan D
Аннотация
OBJECTIVE: To report the first case of monozygotic twins with discordant congenital anomalies.
DESIGN: Descriptive case report.
SETTING: University hospital.
PATIENT(S): A 20-year woman with complete vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome) and right renal agenesis presented for creation of a neovagina. She had a monozygous twin confirmed by DNA testing using short tandem repeat (STR) loci; the twin had normal mullerian/mesonephric development but isolated bilateral tibial longitudinal deficiency.
INTERVENTION(S): The complete history, physical, and laboratory data of both the patient and her twin. Also, operative laparoscopy with creation of a neovagina in the patient.
MAIN OUTCOME MEASURE(S): Diagnosis and appropriate treatment of Mayer-Rokitansky-Kuster-Hauser syndrome and DNA testing with STR loci for monozygosity.
RESULT(S): The surgical resection of the bilateral uterine remnants, creation of a neovagina in the patient, and the demonstration of monozygosity with her twin with bilateral tibial longitudinal deficiency.
CONCLUSION(S): This case report suggests a link between developmental abnormalities of the genital and skeletal system.
DESIGN: Descriptive case report.
SETTING: University hospital.
PATIENT(S): A 20-year woman with complete vaginal agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome) and right renal agenesis presented for creation of a neovagina. She had a monozygous twin confirmed by DNA testing using short tandem repeat (STR) loci; the twin had normal mullerian/mesonephric development but isolated bilateral tibial longitudinal deficiency.
INTERVENTION(S): The complete history, physical, and laboratory data of both the patient and her twin. Also, operative laparoscopy with creation of a neovagina in the patient.
MAIN OUTCOME MEASURE(S): Diagnosis and appropriate treatment of Mayer-Rokitansky-Kuster-Hauser syndrome and DNA testing with STR loci for monozygosity.
RESULT(S): The surgical resection of the bilateral uterine remnants, creation of a neovagina in the patient, and the demonstration of monozygosity with her twin with bilateral tibial longitudinal deficiency.
CONCLUSION(S): This case report suggests a link between developmental abnormalities of the genital and skeletal system.