Expert review of medical devices · 2025
Continuous glucose monitoring predicts glycemic status in postpartum women with a recent history of gestational diabetes.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Elkind-Hirsch Karen E, Armatta Melissa L, Hames Kazanna C, Veillon Edward W
Аннотация
BACKGROUND: Women with a history of gestational diabetes mellitus (GDM) face an elevated risk of developing diabetes, yet postpartum screening is often This study evaluated the diagnostic utility of a blinded continuous glucose monitoring (CGM) system (Dexcom G7) for assessing glycemic status.
METHODS: Of 40 enrolled participants, 39 completed testing at 6-24 weeks postpartum. Assessments included hemoglobin A1c (HbA1c,), fructosamine, a 75-g oral glucose tolerance test (OGTT), and 8-9 days of CGM wear. CGM metrics analyzed were mean glucose and time in range (TIR; 3.9-7.8 mmol/L).
RESULTS: Diabetes and prediabetes were identified in 1 and 9 participants by HbA1c, 3 and 10 by fructosamine, and 4 and 10 by OGTT. CGM metrics detected 4 cases of diabetes and 10 of prediabetes. Mean OGTT glucose correlated strongly with mean CGM glucose (r = 0.66, p < 0.001) and inversely with TIR (r = -0.57, p < 0.001). Paired OGTT and CGM values were highly correlated (r = 0.874; p < 0.001).
CONCLUSION: Postpartum dysglycemia is prevalent after GDM. HbA1c and fructosamine lacked sensitivity and specificity, while CGM performed comparably to OGTT in detecting abnormal glucose metabolism in this postpartum population.Clinical trial registration: www.clinicaltrials.gov identifier is NCT06057805.
METHODS: Of 40 enrolled participants, 39 completed testing at 6-24 weeks postpartum. Assessments included hemoglobin A1c (HbA1c,), fructosamine, a 75-g oral glucose tolerance test (OGTT), and 8-9 days of CGM wear. CGM metrics analyzed were mean glucose and time in range (TIR; 3.9-7.8 mmol/L).
RESULTS: Diabetes and prediabetes were identified in 1 and 9 participants by HbA1c, 3 and 10 by fructosamine, and 4 and 10 by OGTT. CGM metrics detected 4 cases of diabetes and 10 of prediabetes. Mean OGTT glucose correlated strongly with mean CGM glucose (r = 0.66, p < 0.001) and inversely with TIR (r = -0.57, p < 0.001). Paired OGTT and CGM values were highly correlated (r = 0.874; p < 0.001).
CONCLUSION: Postpartum dysglycemia is prevalent after GDM. HbA1c and fructosamine lacked sensitivity and specificity, while CGM performed comparably to OGTT in detecting abnormal glucose metabolism in this postpartum population.Clinical trial registration: www.clinicaltrials.gov identifier is NCT06057805.