Therapeutics and clinical risk management · 2026
Effects of TUS-NMES Combined with Glucocorticoid on Clinical Outcomes and Rehabilitation Efficacy of Neurosyphilis Patients with Cerebral Infarction.
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Dai Jun, He Fanghua, Xu Yating, Lei Na, Zhang Dan, He Wenchao, Zhu Fengfeng, Chen Shuangshuang, Shan Xinyi, Wu Minzhi, Zhang Xuehua
Аннотация
OBJECTIVE: To investigate the effects of transcranial ultrasound-neuromuscular electrical stimulation (TUS-NMES) combined with glucocorticoid (GC) as adjunctive intervention to standard penicillin therapy on clinical outcomes and rehabilitation efficacy in neurosyphilis (NS) patients with cerebral infarction.
METHODS: A total of 309 NS patients with cerebral infarction were randomly divided into general group (N = 79, penicillin), GC group (N = 77, penicillin and GC), TUS-NMES group (N = 75, penicillin and TUS-NMES), and combination group (N = 78, penicillin and GC & TUS-NMES). Baseline data, clinical symptoms, laboratory indicators, Fugl-Meyer assessment scale (FMA), and National Institute of Health stroke scale (NIHSS) scores before and after treatment were compared. Twelve-month rehabilitation outcomes were analyzed using Kaplan-Meier curves.
RESULTS: No serious adverse events occurred during treatment; only mild, transient discomforts, including slight scalp tingling, local muscle tremor, headache, and insomnia, were reported, all of which were alleviated after timely management and did not significantly affect the treatment process or patient recovery. After treatment, all groups showed significant improvement (P < 0.05), with the combination group demonstrating the greatest effect, including prolonged prothrombin time, higher nitric oxide, lower NIHSS, and higher FMA scores. At 12 months, the combination group (43.59%) showed a higher treatment improvement rate than the general (25.32%) and GC (27.27%) groups (P < 0.05), as well as the optimal recovery effect.
CONCLUSION: TUS-NMES combined with GC, as an adjunct to standard penicillin therapy, improves clinical symptoms, coagulation, and neurological function, and enhances rehabilitation outcomes in NS patients with cerebral infarction.
METHODS: A total of 309 NS patients with cerebral infarction were randomly divided into general group (N = 79, penicillin), GC group (N = 77, penicillin and GC), TUS-NMES group (N = 75, penicillin and TUS-NMES), and combination group (N = 78, penicillin and GC & TUS-NMES). Baseline data, clinical symptoms, laboratory indicators, Fugl-Meyer assessment scale (FMA), and National Institute of Health stroke scale (NIHSS) scores before and after treatment were compared. Twelve-month rehabilitation outcomes were analyzed using Kaplan-Meier curves.
RESULTS: No serious adverse events occurred during treatment; only mild, transient discomforts, including slight scalp tingling, local muscle tremor, headache, and insomnia, were reported, all of which were alleviated after timely management and did not significantly affect the treatment process or patient recovery. After treatment, all groups showed significant improvement (P < 0.05), with the combination group demonstrating the greatest effect, including prolonged prothrombin time, higher nitric oxide, lower NIHSS, and higher FMA scores. At 12 months, the combination group (43.59%) showed a higher treatment improvement rate than the general (25.32%) and GC (27.27%) groups (P < 0.05), as well as the optimal recovery effect.
CONCLUSION: TUS-NMES combined with GC, as an adjunct to standard penicillin therapy, improves clinical symptoms, coagulation, and neurological function, and enhances rehabilitation outcomes in NS patients with cerebral infarction.