Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
Essential antiarrhythmic drug accessibility worldwide: a multi-survey study and comprehensive evaluation of access and supply challenges.
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Postema Pieter G, Reijnhout Niels D, Ballacci Federico, Manders Evert A, Hoeksema Wiert F, Toniolo Mauro, Tfelt-Hansen Jacob, Penela Diego, Futyma Piotr, Lane Deirdre A, Casado-Arroyo Ruben, Sarquella-Brugada Georgia, Blom Nico A, Wilde Arthur A M, Hollak Carla E M, Arbelo Elena
Аннотация
AIMS: Antiarrhythmic drugs (AADs) are essential for preventing symptoms, morbidity, and mortality associated with cardiac arrhythmias. However, concerns are increasing about their accessibility. We aimed to assess insights into current access to AADs.
METHODS AND RESULTS: Online surveys were distributed to members of the European Heart Rhythm Association, the Association for European Paediatric and Congenital Cardiology, the European Reference Network GUARD-Heart, and national heart rhythm societies. Responses were obtained from 558 respondents across 80 countries. Among countries included in the main analysis (≥5 respondents; 16 countries within and 7 outside the European Union, n = 298 respondents), only 16-59% of surveyed AADs were considered readily accessible. Accessibility varied substantially by drug: oral flecainide and propranolol were available in 88% of countries, whereas mexiletine solution was available in only 10%. Marked differences in accessibility were reported both between and within countries, with availability also changing over time. Higher-income countries generally reported better access and a greater number of market authorization holders than lower-income countries. National societies' perception was that limited access negatively affected patients' quality of life (72%) and life expectancy (35%), while 73% expected these challenges to persist or worsen in the coming years.
CONCLUSION: Physicians worldwide frequently encounter problems accessing guideline-recommended antiarrhythmic drugs for their patients, which putatively impacts their patients' quality of life and life expectancy. This highlights systemic vulnerabilities that extend across national and institutional boundaries, urging close collaboration among clinicians, policymakers, manufacturers, and institutions to guarantee timely and equitable treatment for all patients.
METHODS AND RESULTS: Online surveys were distributed to members of the European Heart Rhythm Association, the Association for European Paediatric and Congenital Cardiology, the European Reference Network GUARD-Heart, and national heart rhythm societies. Responses were obtained from 558 respondents across 80 countries. Among countries included in the main analysis (≥5 respondents; 16 countries within and 7 outside the European Union, n = 298 respondents), only 16-59% of surveyed AADs were considered readily accessible. Accessibility varied substantially by drug: oral flecainide and propranolol were available in 88% of countries, whereas mexiletine solution was available in only 10%. Marked differences in accessibility were reported both between and within countries, with availability also changing over time. Higher-income countries generally reported better access and a greater number of market authorization holders than lower-income countries. National societies' perception was that limited access negatively affected patients' quality of life (72%) and life expectancy (35%), while 73% expected these challenges to persist or worsen in the coming years.
CONCLUSION: Physicians worldwide frequently encounter problems accessing guideline-recommended antiarrhythmic drugs for their patients, which putatively impacts their patients' quality of life and life expectancy. This highlights systemic vulnerabilities that extend across national and institutional boundaries, urging close collaboration among clinicians, policymakers, manufacturers, and institutions to guarantee timely and equitable treatment for all patients.