Findings from the 2025 AMCP Foundation Symposium: Health Optimization 2.0.

The 2025 AMCP Foundation Symposium: Health Optimization 2.0 convened a select group of just over 70 managed care stakeholders in Dallas, Texas, on December 2-3, 2025. Via presentations and panel sessions, participants examined how precision medicine, data analytics, evolving policy, and health system design can address inequities in care delivery. Focus areas included precision medicine in oncology, vaccine hesitancy, use of data and artificial intelligence, and multiple sclerosis. Following group sessions, participants were divided into work groups and asked to highlight 1 key problem-solution pair for each of 2 assigned focus areas. This article presents a summary of the discussion for key problem-solution pairs in each of the 4 focus areas. The problem-solution pairs identified for vaccine hesitancy all related to delivering positive, community-driven messaging to rebuild eroded public trust. The other focus areas had multiple problems and solutions, which implies that driving meaningful change in these areas may be more complex.