Combined effects of Terminalia bellirica and Glycyrrhiza glabra on ameliorating cisplatin-induced nephrotoxicity in Swiss albino mice.

Terminalia bellirica and Glycyrrhiza glabra are renowned for their medicinal properties and rich antioxidant content. These plants have been integral to Ayurvedic medicine, treating various ailments for centuries. The present study investigated the nephroprotective effects of aqueous methanolic extracts of Terminalia bellirica and Glycyrrhiza glabra in a Cisplatin-induced rodent model. Both in vitro and in vivo analyses were conducted using established biomarkers of renal function, such as serum creatinine, serum urea, blood urea nitrogen, and glomerular filtration rate, to evaluate the nephroprotective effects. In addition to biochemical parameters, renal histopathology was examined through H&E staining, revealing a significant reduction in tubular and glomerular injury following the administration of the plant extracts.