Nature communications · 2020
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Huhn Oisín, Ivarsson Martin A, Gardner Lucy, Hollinshead Mike, Stinchcombe Jane C, Chen Puran, Shreeve Norman, Chazara Olympe, Farrell Lydia E, Theorell Jakob, Ghadially Hormas, Parham Peter, Griffiths Gillian, Horowitz Amir, Moffett Ashley, Sharkey Andrew M, Colucci Francesco
Аннотация
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass cytometry, we characterise five main dILC subsets: decidual NK cells (dNK)1-3, ILC3s and proliferating NK cells. Following stimulation, dNK2 and dNK3 produce more chemokines than dNK1 including XCL1 which can act on both maternal dendritic cells and fetal EVT. In contrast, dNK1 express receptors including Killer-cell Immunoglobulin-like Receptors (KIR), indicating they respond to HLA class I ligands on EVT. Decidual NK have distinctive organisation and content of granules compared with peripheral blood NK cells. Acquisition of KIR correlates with higher granzyme B levels and increased chemokine production in response to KIR activation, suggesting a link between increased granule content and dNK1 responsiveness. Our analysis shows that dILCs are unique and provide specialised functions dedicated to achieving placental development and successful reproduction.