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Войти в исследования Neurological manifestations by sex and age group in COVID-19 inhospital patients.
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Pereira Daniella Nunes, Bicalho Maria Aparecida Camargos, Jorge Alzira de Oliveira, Gomes Angélica Gomides Dos Reis, Schwarzbold Alexandre Vargas, Araújo Anna Luiza Homan, Cimini Christiane Corrêa Rodrigues, Ponce Daniela, Rios Danyelle Romana Alves, Grizende Genna Maira Santos, Manenti Euler Roberto Fernandes, Anschau Fernando, Aranha Fernando Graça, Bartolazzi Frederico, Batista Joanna d'Arc Lyra, Tupinambás Julia Teixeira, Ruschel Karen Brasil, Ferreira Maria Angélica Pires, Paraíso Pedro Gibson, Araújo Silvia Ferreira, Teixeira Antonio Lucio, Marcolino Milena Soriano
Аннотация
METHODS: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group.
RESULTS: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22-1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20-0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18-39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06-1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00-1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02-1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98-0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98-0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98-0.99) decreased (p < 0.001 for all).
CONCLUSION: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.