Atherosclerosis · 2026
Association of albuminuria and changes in albuminuria with the risk of abdominal aortic aneurysm.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Tanaka Shigeru, Bosi Alessandro, Nakano Toshiaki, Hultgren Rebecka, Matsushita Kunihiro, Carrero Juan Jesus, Faucon Anne-Laure
Аннотация
BACKGROUND AND AIMS: Studies investigating the association between chronic kidney disease and abdominal aortic aneurysm (AAA) risk focus on estimated glomerular filtration rate (eGFR) rather than albuminuria. Albuminuria is an earlier, modifiable marker of kidney damage. This study explored whether albuminuria predicts AAA risk independently of eGFR.
METHODS: Observational study using healthcare records of Stockholm residents free from AAA who underwent routine creatinine testing during 2006-2021. Cox regression evaluated the association between a single point albuminuria or the change within two years and the rate of a de novo diagnosis AAA and fatal-AAA (death within 30 days).
RESULTS: There were total 751 794 participants (mean age 55 years, 53% women, mean eGFR 90 mL/min/1.73 m2, median albuminuria 15.9 mg/g). Over a median follow-up of 6.1 years, 3861 (0.51%) developed AAA, of which 245 (0.03%) were fatal. Compared to albuminuria <30 mg/g, moderate (30-299 mg/g) or severe (≥300 mg/g) albuminuria increased AAA risk by 33% (HR 1.33; 95% CI 1.23-1.44) and 49% (HR 1.49; 1.28-1.73), respectively. HRs for fatal-AAA were 2.01 (95% CI 1.52-2.68) and 2.02 (1.19-3.44). AAA (61 fatal). Among 122 756 participants with repeat measures, a 2- to 4-fold albuminuria rise increased AAA risk by 30% (HR 1.30 [1.03-1.64]); a ≥4-fold rise increased risk by 68% (HR 1.68 [1.12-2.50]), irrespective of baseline albuminuria, eGFR, and the rate of eGFR decline.
CONCLUSIONS: In this large community-based study, albuminuria levels and worsening albuminuria were associated with higher AAA risk, independently of eGFR.
METHODS: Observational study using healthcare records of Stockholm residents free from AAA who underwent routine creatinine testing during 2006-2021. Cox regression evaluated the association between a single point albuminuria or the change within two years and the rate of a de novo diagnosis AAA and fatal-AAA (death within 30 days).
RESULTS: There were total 751 794 participants (mean age 55 years, 53% women, mean eGFR 90 mL/min/1.73 m2, median albuminuria 15.9 mg/g). Over a median follow-up of 6.1 years, 3861 (0.51%) developed AAA, of which 245 (0.03%) were fatal. Compared to albuminuria <30 mg/g, moderate (30-299 mg/g) or severe (≥300 mg/g) albuminuria increased AAA risk by 33% (HR 1.33; 95% CI 1.23-1.44) and 49% (HR 1.49; 1.28-1.73), respectively. HRs for fatal-AAA were 2.01 (95% CI 1.52-2.68) and 2.02 (1.19-3.44). AAA (61 fatal). Among 122 756 participants with repeat measures, a 2- to 4-fold albuminuria rise increased AAA risk by 30% (HR 1.30 [1.03-1.64]); a ≥4-fold rise increased risk by 68% (HR 1.68 [1.12-2.50]), irrespective of baseline albuminuria, eGFR, and the rate of eGFR decline.
CONCLUSIONS: In this large community-based study, albuminuria levels and worsening albuminuria were associated with higher AAA risk, independently of eGFR.