International journal of clinical oncology · 2026
Efficacy of a new surgical indicator for lung cancer with interstitial lung disease based on the gender-age-physiology staging system.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Imamura Yoshito, Nakanishi Keita, Huang Heng, Sugihara Minoru, Ryo Taiki, Ichikawa Yasuhisa, Masuda Tatsuya, Takenaka Hirofumi, Kawasumi Yuta, Watanabe Hiroki, Kadomatsu Yuka, Ueno Harushi, Kato Taketo, Nakamura Shota, Mizuno Tetsuya, Chen-Yoshikawa Toyofumi Fengshi
Аннотация
BACKGROUND: Selecting the optimal surgical strategy for lung cancer patients with interstitial lung disease (ILD) remains difficult. This study evaluated the prognostic value of a newly proposed surgical indicator-the predicted ILD Gender-Age-Physiology (GAP) stage-which incorporates predicted postoperative pulmonary function into the conventional ILD-GAP stage.
METHODS: This study retrospectively analyzed 125 patients with clinical stage 1 lung cancer and ILD who underwent surgery during 2011-2023. Postoperative outcomes were compared according to surgical procedure and predicted ILD-GAP stage.
RESULTS: The 5-year overall survival (OS) rate was markedly superior in patients who underwent anatomical resection with a predicted ILD-GAP stage ≤ 2 than in those who underwent wedge resection (75.0% vs. 21.3%, p < 0.001). In contrast, survival did not differ between anatomical resection with a predicted ILD-GAP stage 3 and wedge resection (27.8% vs. 21.3%, p = 0.934). Multivariate analysis identified diffusing capacity of carbon monoxide (p = 0.043), anatomical resection with a predicted ILD-GAP stage ≤ 2 (p = 0.009), and pathological stage 1 (p = 0.035) as independent predictors of prognosis. Furthermore, the predicted ILD-GAP stage provided superior prognostic accuracy for 5-year OS compared with the original ILD-GAP stage (area under the curve: 0.735 vs. 0.653; p = 0.040).
CONCLUSIONS: The proposed surgical indicator enhanced prognostic stratification in lung cancer patients with ILD. In particular, anatomical lung resection in patients with a predicted ILD-GAP stage ≤ 2 was identified as an independent favorable prognostic factor for 5-year OS, highlighting the importance of surgical planning.
METHODS: This study retrospectively analyzed 125 patients with clinical stage 1 lung cancer and ILD who underwent surgery during 2011-2023. Postoperative outcomes were compared according to surgical procedure and predicted ILD-GAP stage.
RESULTS: The 5-year overall survival (OS) rate was markedly superior in patients who underwent anatomical resection with a predicted ILD-GAP stage ≤ 2 than in those who underwent wedge resection (75.0% vs. 21.3%, p < 0.001). In contrast, survival did not differ between anatomical resection with a predicted ILD-GAP stage 3 and wedge resection (27.8% vs. 21.3%, p = 0.934). Multivariate analysis identified diffusing capacity of carbon monoxide (p = 0.043), anatomical resection with a predicted ILD-GAP stage ≤ 2 (p = 0.009), and pathological stage 1 (p = 0.035) as independent predictors of prognosis. Furthermore, the predicted ILD-GAP stage provided superior prognostic accuracy for 5-year OS compared with the original ILD-GAP stage (area under the curve: 0.735 vs. 0.653; p = 0.040).
CONCLUSIONS: The proposed surgical indicator enhanced prognostic stratification in lung cancer patients with ILD. In particular, anatomical lung resection in patients with a predicted ILD-GAP stage ≤ 2 was identified as an independent favorable prognostic factor for 5-year OS, highlighting the importance of surgical planning.