Adult-Onset Still's Disease Associated With Hyperimmunoglobulin-E: A Case Report.

Adult-onset Still's disease (AOSD) is a rare, chronic, multisystem inflammatory disorder of unknown etiology. Diagnosis is made clinically and can be challenging. AOSD typically affects young adults but can occur in older patients. The association between AOSD and very high immunoglobulin-E levels (also known as hyperimmunoglobulin-E) is not well studied. In this report, we present the case of a middle-aged woman with AOSD who presented with more than two weeks of fever, severe generalized weakness, and sore throat, and responded very well to prednisone. She was found to have hyperimmunoglobulin-E without a history of allergic disease or parasitic infection.