Journal of pediatric endocrinology & metabolism : JPEM · 2013
Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Lapid Oren, van Wingerden Jan J, Perlemuter Leon
Аннотация
OBJECTIVE: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia.
DATA SOURCES: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®.
STUDY SELECTION: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents.
OUTCOME MEASURE: Resolution of gynecomastia.
RESULTS: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed.
CONCLUSION: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.
DATA SOURCES: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®.
STUDY SELECTION: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents.
OUTCOME MEASURE: Resolution of gynecomastia.
RESULTS: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed.
CONCLUSION: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.